منابع مشابه
Regression kinetics of mouse skin papillomas.
The persistence and proliferation rate of mouse skin papillomas were studied in HA/ICR mice initiated with 7,12-dimethylbenz(a)anthracene and promoted three times weekly with phorbol myristate acetate. When the promoter treatments were stopped, rapid (half-time, 24 days) and slow (half-time, greater than 140 days) components of papilloma regression were observed. When the promoter dose was incr...
متن کاملFollicular origin of epidermal papillomas in v-Ha-ras transgenic TG.AC mouse skin.
A follicular origin for some skin tumors has been hypothesized in both humans and animal models. Because of its rapid and sensitive response to tumor promoter treatment, a v-Ha-ras transgenic (TG.AC) mouse line was used to determine the origins of epidermal papillomas. Using histological studies and transgene expression as a marker for papilloma development, we determined that pedunculated papi...
متن کاملPolyclonal origin and hair induction ability of dermal papillae in neonatal and adult mouse back skin
Hair follicle development and growth are regulated by Wnt signalling and depend on interactions between epidermal cells and a population of fibroblasts at the base of the follicle, known as the dermal papilla (DP). DP cells have a distinct gene expression signature from non-DP dermal fibroblasts. However, their origins are largely unknown. By generating chimeric mice and performing skin reconst...
متن کاملPolyclonal origin of pancreatic islets in aggregation mouse chimaeras.
In the present study, we have examined the origin and growth pattern of the beta cells in pancreatic islets, to determine whether a single progenitor cell gave rise to all the precursors of the islets, or if each of a few progenitor cells is the founder of a different islet, or if each islet is a mixture of cells originating from a pool of progenitor cells. Aggregation mouse chimaeras where the...
متن کاملFatal Keratomas Due to Deep Homografts of the Benign Papillomas of Tarred Mouse Skin
Six out of eight epidermal papillomas, induced with tar in mice of homogeneous strain, have grown after transfer to the subcutaneous tissue of sucklings and weanlings. Five of them have been thus maintained for nearly or quite a year and a half, and in seven to nine successive groups of mice. The tumor studied longest has been kept going in five parallel lines since its primary implantation. Th...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1989
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1989.220